Glucosamine and chondroitin are two common supplements people with arthritis can use to find relief, as these are natural components of cartilage. Polyunsaturated omega-3 fatty acids may also reduce inflammation; however, they seem to work better for rheumatoid arthritis than for osteoarthritis, according to Chris D'Adamo, Ph.D., of the University of Maryland School of Medicine Center for Integrative Medicine.