How CBD Oil Really Works For Pain Management

Cannabidiol (CBD) oil is an extract derived from the cannabis plant that is often used for medicinal purposes. While there is limited research on CBD oil due to the legal restrictions placed on the research and use of cannabis, some people report using CBD to treat and manage pain, anxiety, and depression (via Medical News Today).

Unlike tetrahydrocannabinol (THC), CBD can't get you high, but it may reduce pain, inflammation, and general discomfort. That's because CBD is a different compound that affects the endocannbionoid system, which helps regulate sleep, pain sensation, and immune response.

In fact, CBD can increase the amount of anandamide in the body — an endocannabinoid that can suppress pain and temporarily improve your mood. While there is not enough conclusive evidence to say anything for certain, small studies on animals on humans have shown that CBD may be a promising pain relief option for people with chronic pain, arthritis, and nerve pain.

Even though research on CBD oil is limited, CBD is generally considered safe and well-tolerated by most people. According to a 2017 report from the World Health Organization (WHO), there is no evidence that pure CBD is associated with abuse, dependence, or any other health-related issues (via Everyday Health). However, that doesn't mean that CBD oil is completely free of side effects. Like with any drug, some people will tolerate it better than others.

Possible side effects of CBD oil include fatigue, diarrhea, changes in appetite, and weight gain or weight loss. CBD oil may also interfere with supplements, over-the-counter drugs, and prescription medications, especially those that contain a grapefruit warning (via Healthline). That's because both grapefruit and CBD interfere with the CYP3A4 enzyme in the small intestine, which is responsible for metabolizing medications. Consuming grapefruit or CBD on certain medications can leave too much of the drug in your bloodstream, increasing negative side effects.