Here Are Ozempic's Increased Risks For People Over 50

Ozempic is an FDA-approved injectable medication taken once a week to lower blood sugar levels in patients with type 2 diabetes and protect against related cardiovascular events in patients also diagnosed with heart disease (via Ozempic). When paired with regular physical activity and a healthy diet, research has shown that most patients using Ozempic achieve recommended A1C levels of below 7%. Cleveland Clinic experts explain that A1C tests are used to determine one's average glucose levels throughout the past three months. Ozempic may also be prescribed off-label for weight loss.

Although the drug is intended for adults, there are special considerations for people over the age of 50, primarily those related to Ozempic's main ingredient, semaglutide. "As we age, a couple things to keep a close eye on, one of [which is] reduced kidney function," Dr. Jason Singh, Chief Medical Officer and Physician at One Oak Medical, told Health Digest in an interview. "Since semaglutide is primarily eliminated through the kidneys, decreased kidney function could potentially lead to semaglutide accumulation." According to the Mayo Clinic, there is such a thing as semaglutide overdose, in which a person may experience vomiting, dehydration, dangerous drops in blood sugar levels, and may be more susceptible to pancreatitis. Doctors will therefore want to be vigilant about monitoring kidney function in older adults prescribed the medication.

Like all drugs, Ozempic comes with potential side effects, with vomiting, nausea, diarrhea, stomach pain, and constipation being among those most reported (via Ozempic). Dr. Jason Singh explains that some of these side effects may be more severe in patients over 50. "Age-related changes in GI tract function may exacerbate common side effects like nausea and delayed gastric emptying," he states. "Older adults are more susceptible to dehydration, which could be compounded by the potential gastrointestinal side effects."

The older we get, the more medications we may find ourselves taking, as Dr. Singh alternatively points out to us. This creates more opportunities for potential drug interactions. Any and all drugs taken, including supplements, over-the-counter meds, vitamins, insulin, and more, should be discussed thoroughly with your physician. To reduce the risk of potential drug interactions, older patients are advised to drink plenty of water. Your doctor should also closely monitor your medication usage and may suggest starting off with small doses before gradually increasing the amount.

For patients older than 50, Dr. Jason Singh says that age and health status become more relevant in deciding whether or not a patient may be well suited for Ozempic treatment. "One [factor] is life expectancy, as long-term benefits of improved glycemic control may be less relevant in very advanced age or severe comorbidities," he says. Dr. Singh further notes that weight loss side effects associated with the drug may make particularly frail adults more vulnerable to falls and additional muscle loss. Cognitive health is also a factor to consider. Patients with dementia or Alzheimer's disease, for example, may experience difficulty sticking to a strict medication schedule or recognizing side effects.

All that being said, turning 50 should not be considered a deadline by which Ozempic is no longer safe for use. Discussing all your questions, concerns, benefits, and potential risks at length with your healthcare provider can help you and your doctor determine whether Ozempic is a safe and practical treatment option for you.

To learn more about Dr. Jason Singh, connect with him on Instagram @drjaysonisfresh or visit oneoakmed.com.